Quantifying Baseline Fixed Charge Density in Healthy Human Cartilage Endplate
نویسندگان
چکیده
منابع مشابه
Analysis of cartilage matrix fixed charge density and three-dimensional morphology via contrast-enhanced microcomputed tomography.
Small animal models of osteoarthritis are often used for evaluating the efficacy of pharmacologic treatments and cartilage repair strategies, but noninvasive techniques capable of monitoring matrix-level changes are limited by the joint size and the low radiopacity of soft tissues. Here we present a technique for the noninvasive imaging of cartilage at micrometer-level resolution based on detec...
متن کاملCompartmentalization Evaluated to Explain Discrepancies Calculating Cartilage Fixed Charge
Recent studies on methods of detecting the early onset of arthritic cartilage degradation using NMR-based techniques have shown that such detection is possible. The use of sodium NMR observations, along with an ideal Donnan single compartment model of cartilage, has already been validated as a means of measuring cartilage fixed charge density a known indicator of cartilage condition. Similar ca...
متن کاملExtracellular Fixed Charge Density and Osmotic Effects on Chondrocyte Proteoglycan Replenishment after Enzymatic Digestion of Cartilage Explants
INTRODUCTION Chondrocytes maintain a balance between catabolic and anabolic activities in order to provide cartilage tissue with its characteristic concentrations of extracellular matrix molecules such as glycosaminoglycans (GAGs) and collagen. Disruption of this balance may have implications for disease progression and loss of tissue properties. As demonstrated in a recent study [1], when the ...
متن کاملLigustrazine Inhibits Cartilage Endplate Hypertrophy via Suppression of TGF-β1
CEP hypertrophy is one of the characteristics of intervertebral disc degeneration (IDD). LIG exerts a protective effect on IDD in animal model. The effect of LIG on CEP hypertrophy is further investigated in the present study. Cells were isolated from hypertrophic samples obtained from patients during vertebral fusion surgery. Cellular proliferation and the expression of type I collagen (Col I)...
متن کاملCharacteristics of Stem Cells Derived from the Degenerated Human Intervertebral Disc Cartilage Endplate
Mesenchymal stem cells (MSCs) derived from adult tissues are an important candidate for cell-based therapies and regenerative medicine due to their multipotential differentiation capability. MSCs have been identified in many adult tissues but have not reported in the human intervertebral disc cartilage endplate (CEP). The initial purpose of this study was to determine whether MSCs exist in the ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Spine
سال: 2017
ISSN: 0362-2436,1528-1159
DOI: 10.1097/brs.0000000000002061